Oncologists Call for Reduced Dosing of Keytruda Amid Rising Costs
To lower cost burden, oncologists suggest smaller doses, but Keytruda says no
The Indian Express
Image: The Indian Express
Experts in India are advocating for lower doses of Keytruda, a leading cancer drug, to alleviate financial burdens on patients. Current practices by Merck & Co. have led to unnecessarily high costs and over-medication, while a shift towards weight-based dosing could improve accessibility and treatment effectiveness.
- 01Experts recommend lower doses of Keytruda to reduce costs for patients in India.
- 02Merck & Co. has standardized high dosing, contributing to increased financial strain on cancer patients.
- 03Keytruda's flat dosing model results in patients receiving more medication than necessary.
- 04Research shows that lower doses can be as effective as the standard dosage.
- 05Barriers include Merck's refusal to acknowledge weight-based dosing and the lack of smaller vial sizes.
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Keytruda, a cancer drug developed by Merck & Co., has become a financial burden for many patients in India due to its high cost and fixed dosing model. Approved by the U.S. Food and Drug Administration (FDA) in 2014, Keytruda is now widely used for various cancers, generating approximately $29.5 billion in revenue for 2024. However, oncologists argue that the standardized 200mg dose, regardless of patient weight, leads to over-medication and increased costs. Experts suggest that a shift towards weight-based dosing could make the drug more accessible and effective. Studies indicate that a lower dose of 50mg every six weeks can yield similar results to the standard dose, yet Merck's patient assistance programs only cover the higher dosage. Additionally, the drug is only available in 100mg vials, complicating the administration of smaller doses. This situation has led to calls for changes in treatment protocols to ensure that patients can afford and access necessary cancer therapies.
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The high cost of Keytruda limits access for many cancer patients in India, leading to calls for more affordable treatment options.
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