US Vice President JD Vance's diplomatic efforts in Islamabad to negotiate with Iran ended without an agreement after 21 hours of talks. This meeting was significant as it was the first high-level political contact between the US and Iran since the 1979 Islamic Revolution. Vance stated, 'They have chosen not to accept our terms,' underscoring the challenges faced during negotiations. Key issues included the reopening of the Strait of Hormuz, which is vital for global energy supply, and Iran's nuclear program, where the US proposed a take-it-or-leave-it offer to terminate Iran's nuclear activities. Iran's demand for the release of $27 billion in frozen assets for reconstruction post-conflict was also a major sticking point. Although the talks did not yield immediate results, both parties showed a willingness to negotiate further, leaving the door open for future discussions. However, regional tensions, particularly Israel's military actions in Lebanon, may complicate the negotiation process and influence the next steps for both the US and Iran.