The Australian Centre for Disease Control (CDC) has been established as a statutory independent authority to enhance national health surveillance and pandemic preparedness. Prof. Zoe Wainer, the inaugural director general, expressed her enthusiasm for leading this initiative, which aims to ensure Australia is never caught off guard by health threats. The CDC will prioritize connecting state and federal data surveillance, addressing weaknesses identified during the COVID-19 pandemic. Additionally, it will adopt a 'One Health' approach, recognizing the interdependence of human, animal, and environmental health. Wainer emphasized the importance of transparency and community engagement to counter misinformation, which has contributed to the resurgence of preventable diseases. With a strong background in public health and social justice, Wainer is committed to integrating diverse perspectives, including collaboration with First Nations peoples. Her family's legacy in public health advocacy further informs her dedication to improving health outcomes for all Australians.