Khartoon Weiss, who led TikTok's advertising efforts in North America, is resigning after nearly six years with the company. Weiss's exit follows a series of high-profile departures, including Kim Farrell, the global head of creators, and Blake Chandlee, who managed advertising and marketing. Weiss was instrumental in overseeing TikTok's global brands and agency business, and her resignation comes as TikTok navigates a complex regulatory landscape. In March, she highlighted the company's commitment to growth, stating, "We’re going to kick into fifth gear." Despite Weiss's departure, TikTok's parent company, ByteDance, remains firmly in control of its advertising operations, having restructured parts of its U.S. business earlier this year as part of a national security agreement. The search for Weiss's replacement is currently underway, as reported in a memo to advertisers.