A recent study published in the *Annals of Internal Medicine* by researchers at the University of North Carolina School of Medicine reveals that weight loss from popular incretin-based medications, such as semaglutide and tirzepatide, can lead to significant muscle loss. The study, led by Dr. John A. Batsis, an expert in obesity and nutrition, analyzed data from 19 studies and found that muscle-related tissue accounted for approximately 35% of total weight lost in individuals using these drugs, exceeding safe limits in 68% of cases. While these medications effectively aid in weight reduction and manage type 2 diabetes by suppressing appetite, they also contribute to lean mass loss, particularly concerning for older adults who may already have diminished muscle quality. The study indicates that muscle loss can lead to a range of health issues, including increased frailty, risk of falls, and slower recovery from injuries. To counteract muscle loss, the researchers recommend incorporating resistance training, consuming a high-protein diet, and maintaining overall physical activity. These lifestyle changes can help preserve muscle mass during weight loss efforts.